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KMID : 1148020150400040145
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조선대학교의대논문집
2015 Volume.40 No. 4 p.145 ~ p.148
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The Effects of Ulinastatin against the Development of Neuropathic Pain Is Involved with Changing the Levels of IL-6, not IL-10
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Park Jun-Hee
Oh Seon-Hee
Kim Dong-Jun
Jong Hwa-Song
Kim Sang-Hun
Lim Kyung-Joon
Yoon Myung-Ha
Jung Ki-Tae
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Abstract
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Background: We evaluated the effect of ulinastatin on paw withdrawal threshold (PWT), IL-6, and IL-10 in SD rats after
spinal nerve ligation (SNL).
Methods: Group C received N/S and Group E received ulinastatin IV for three days following
SNL. PWT, IL-6, and IL-10 were measured on the 3rd, 5th, and 7th day.
Results: Group E showed higher PWT compared to
group C. IL-6 was lower in group E than in group C. No differences in IL-10 were observed between group C and group E.
Conclusion: Ulinastatin increased the PWT and its effect appears to be involved with IL-6, not IL-10.
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KEYWORD
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Interleukin-6, Interleukin-10, Neuropathic pain, Rats, Urinary trypsin inhibitor
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