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KMID : 1148020150400040179
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조선대학교의대논문집
2015 Volume.40 No. 4 p.179 ~ p.180
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Coexistence of Chronic Myelogenous Leukemia and Diffuse Large B-Cell Lymphoma
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Lee Hee-Jeong
Chung Choon-Hae
Park Chi-Young
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Abstract
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Diagnosis of chronic myelogenous leukemia (CML) and non-Hodgkins lymphoma (NHL) have rarely been made simultaneously in the same patient. We report a rare case of a patient with CML-chronic phase who developed a concurrent Philadelphia (Ph)-negative diffuse large B-cell lymphoma. At the time of diagnosis, cytogenetic analysis of peripheral blood and bone marrow cells revealed the Ph-chromosome translocation in all examined metaphases. A lymph node biopsy showed features of diffuse large B-cell lymphoma, and fluorescence in situ hybridization (FISH) of lymph node tissue for BCR-ABL was negative. The patient was treated with R-CHOP (rituximab, cyclophosphamide, vincristine, adriamycin and prednisone) and imatinib mesylate.
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KEYWORD
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chronic myelogenous leukemia, non-Hodgkins lymphoma
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