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KMID : 1148020180430020088
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조선대학교의대논문집
2018 Volume.43 No. 2 p.88 ~ p.93
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Clinical Manifestation of Enteroviral Meningitis without Cerebrospinal Fluid (CSF) Pleocytosis in Children
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Cho Chul-Jun
Nam Myoung-Soo
Kim Yong-Wook
Kim Kyoung-Sim
Cho Hyoung-Min
Kim Young
Jang Hae-In
Kim Eun-Young
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Abstract
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The aim of this study was to investigate the factors associated with cerebrospinal fluid (CSF) pleocytosis in pediatric enteroviral meningitis. A retrospective analysis of the medical records was performed in 281 patients under 18 years of age who were diagnosed with enteroviral meningitis by reverse transcription-polymerase chain reaction (RT-PCR) at Kwangju Christian Hospital from January to December 2016. Clinical symptoms and laboratory findings were compared according to the presence or absence of CSF pleocytosis. 112 children (39.9%) did not have CSF pleocytosis. When we compared the group of meningitis without pleocytosis and the group with pleocytosis, age were younger (< 2years), and the interval between onset of symptoms and the time of lumbar puncture was shorter (<24 hours), peripheral white blood cell counts were lower, but C-reactive protein (CRP) was higher in the group of meningitis without pleocytosis. Enteroviral meningitis should not be excluded even if CSF pleocytosis is not seen in patients. And enterovirus CSF RT-PCR should be performed with high suspicion in children younger than 2 years.
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KEYWORD
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Cerebrospinal fluid, Pediatrics, Enterovirus, Meningitis, RT-PCR
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