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KMID : 1148020220470020027
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조선대학교의대논문집
2022 Volume.47 No. 2 p.27 ~ p.34
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Comparison of prognostic factors according to tumor size in T1 breast cancer
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Ahn Woo-Jun
Kim Kweon-Cheon
Choi Si-Hyun
Kim Yoo-Seok
Lee Mi-Ja
Lim Sung-Chul
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Abstract
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Purpose: The incidence rate and the rate of early breast cancer diagnosis has improved. This study evaluated the prognosis for patients with small-sized, T1 breast cancer.
Methods: A retrospective study was conducted based on 333 patients diagnosed with T1 breast cancer ≤2cm in diameter. The patients were further subdivided into categories of T1a/T1b (≤1 cm tumor size) or T1c (>1 cm, but ≤2 cm tumor size)
Results: Axillary lymph node metastasis was found with greater frequency in the T1c compared to the T1ab group (27.9% vs. 17.6% of patients; not statistically significant). Lympho-vascular invasion was found with a statistically significantly greater frequency in the T1c compared to the T1ab group (29.2% vs. 16.2%, p=0.004). An increase in tumor size is a poor prognostic factor that lead to increased disease recurrence or decreased survival in patients with T1 breast cancer.
Conclusion: Axillary lymph node metastasies and lympho-vascular invasion were found to be poor prognosis factors in patients with small-sized, T1 breast cancer. These prognostic factors occurred more frequently in the T1c group than in the T1ab group. An increase in tumor size is a poor prognostic factor even in small-sized breast cancer.
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KEYWORD
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breast neoplasms, axilla, lymph nodes, neoplasm invasiveness, risk factors
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