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KMID : 1148020220470020044
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조선대학교의대논문집
2022 Volume.47 No. 2 p.44 ~ p.48
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Crohn's disease with NOD2 gene mutation diagnosed in a patient with fever of unknown origin
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Park Bo-Kyoung
Kim Young
Kim Hyun-Jong
Kim Yong-Wook
Kim Kyoung-Sim
Kim Eun-Young
Cho Hyoung-Min
Jang Hae-In
Kim Seo-Hee
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Abstract
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We apply the term Fever of unknown origin (FUO) to children with fever >38 of at least eight days' duration, in whom no diagnosis is apparent after initial evaluation. Fever is a prominent component of inflammatory bowel disease (IBD), especially Crohn’s disease(CD), in many children and may be more common than abdominal symptoms. The pediatric CD rate is rapidly increasing and pediatric onset IBD represents ≥ 25% of all IBD diagnoses. The nucleotide-binding oligomerization domain (NOD) protein is belonging to the intracellular NOD-like receptor family. NOD2 was the first and is the most replicated locus associated with IBD. In this paper, authors report a case of Crohn’s disease with FUO and NOD2 mutation in a 12-year-old girl.
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KEYWORD
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FUO, NOD2 mutation, Crohn’s disease
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