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KMID : 1148920080420050337
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Nuclear Medicine and Molecular Imaging
2008 Volume.42 No. 5 p.337 ~ p.346
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Nanomedicine: Drug Delivery Systems and Nanoparticle Targeting
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Youn Hye-Won
Kang Keon-Wook
Chung June-Key
Lee Dong-Soo
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Abstract
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Applications of nanotechnology in the medical field have provided the fundamentals of tremendous improvement n precise diagnosis and customized therapy. Recent advances in nanomedicine have led to establish a new concept of theragnosis, which utilizes nanomedicines as a therapeutic and diagnostic tool at the same time. The development of high affinity nanoparticles with large surface area and functional groups multiplies diagnostic and therapeutic capacities. Considering the specific conditions related to the disease of individual patient, customized therapy requires the identification of disease target at the cellular and molecular level for reducing side effects and enhancing therapeutic efficiency. Well-designed nanoparticles can minimize unnecessary exposure of cytotoxic drugs and maximize targeted localization of administrated drugs. This review will focus on major pharmaceutical nanomaterials and nanoparticles as key components of designing and surface engineering for targeted theragnostic drug development. (Nucl Med Mol Imaging 2008;42(5):337-346)
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KEYWORD
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nanomedicine, nanoparticle, drug delivery system, targeting, PEGylation, theragnosis
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