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KMID : 1148920080420060456
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Nuclear Medicine and Molecular Imaging
2008 Volume.42 No. 6 p.456 ~ p.463
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Clinical Significance of Focal Breast Lesions Incidentally Identified by 18F-FDG PET/CT
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Cho Young-Seok
Choi Joon-Young
Lee Su-Jin
Hyun Seung-Hyup
Lee Kyung-Han
Kim Byung-Tae
Choe Yearn-Seong
Lee Ji-Young
Choi Yong
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Abstract
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Purpose: We evaluated the incidence and malignant risk of focal breast lesions incidentally detected by 18F-FDG PET/CT. Various PET/CT findings of the breast lesions were also analyzed to improve the differentiation between benign from malignant focal breast lesions.
Materials & Methods: The subjects were 3,768 consecutive 18F-FDG PET/CT exams performed in adult females without a history of breast cancer. A focal breast lesion was defined as a focal 18F-FDG uptake or a focal nodular lesion on CT image irrespective of 18F-FDG uptake in the breasts. The maximum SUV and CT pattern of focal breast lesions were evaluated, and were compared with final diagnosis.
Results: The incidence of focal breast lesions on PET/CT in adult female subjects was 1.4% (58 lesions in 53 subjects). In finally confirmed 53 lesions of 48 subjects, 11 lesions of 8 subjects (20.8%) were proven to be malignant. When the PET/CT patterns suggesting benignancy (maximum attenuation value > 75 HU or < 30 HU; standard deviation of mean attenuation > 20) were added as diagnostic criteria of PET/CT to differentiate benign from malignant breast lesions along with maximum SUV, the area under ROC curve of PET/CT was significantly increased compared with maximum SUV alone (0.680±0.093 vs. 0.786±0.076, p<0.05).
Conclusion: The malignant risk of focal breast lesions incidentally found on 18F-FDG PET/CT is not low, deserving further diagnostic confirmation. Image interpretation considering both 18F-FDG uptake and PET/CT pattern may be helpful to improve the differentiation from malignant and benign focal breast lesion.
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KEYWORD
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PET/CT, 18F-FDG, breast, cancer screening
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