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KMID : 1148920080420060488
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Nuclear Medicine and Molecular Imaging
2008 Volume.42 No. 6 p.488 ~ p.490
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Significant Mismatch between FDG Uptake and Size after Chemotherapy in a Patient with Non-small Cell Lung Cancer
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Kwon Seong-Young
Min Jung-Joon
Song Ho-Chun
Bom Hee-Seung
Seo Young-Soon
Jeong Shin-Young
Ha Jung-Min
Chong A-Ri
Oh Jong-Ryool
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Abstract
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A 75-year-old man with non-small cell lung cancer (NSCLC) underwent F-18 fluorodeoxyglucose (FDG) PET/CT for staging. PET/CT showed distant metastases to intra-abdominal lymph nodes (LNs) as well as bilateral mediastinal LNs (stage IV). He underwent PET/CT (restaging PET/CT) 1 week after the completion of first-line chemotherapy (docetaxel + carboplatin). It showed markedly increased FDG uptake in primary tumor, whereas tumor size decreased significantly, compared to prior PET/CT. This lesion was aggravated on follow-up CT 3 months after the completion of chemotherapy. Although there are several reports that FDG PET has potential to evaluate early response to chemotherapy and prognosis, there are a few cases to show mismatch between FDG uptake and size on PET/CT. Thus we report a case of NSCLC showed increased FDG uptake of primary tumor while decreased tumor size on restaging PET/CT.
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KEYWORD
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Non-small cell lung cancer, mismatch, FDG, size
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