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KMID : 1148920090430060513
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Nuclear Medicine and Molecular Imaging
2009 Volume.43 No. 6 p.513 ~ p.518
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Added Value of 3D Cardiac SPECT/CTA Fusion Imaging in Patients with Reversible Perfusion Defect on Myocardial Perfusion SPECT
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Kong Eun-Jung
Cho Ihn-Ho
Kang Won-Jun
Kim Seong-Min
Won Kyoung-Sook
Lim Seok-Tae
Hwang Kyung-Hoon
Lee Byeong-il
Bom Hee-Seung
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Abstract
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Purpose: Integration of the functional information of myocardial perfusion SPECT (MPS) and the morpho- anatomical information of coronary CT angiography (CTA) may provide useful additional diagnostic information of the spatial relationship between perfusion defects and coronary stenosis. We studied to know the added value of three dimensional cardiac SPECT/CTA fusion imaging (fusion image) by comparing between fusion image and MPS.
Materials and Methods: Forty-eight patients (M:F=26:22, Age: 63.3±10.4 years) with a reversible perfusion defect on MPS (adenosine stress/rest SPECT with Tc-99m sestamibi or tetrofosmin) and CTA were included. Fusion images were molded and compared with the findings from the MPS. Invasive coronary angiography served as a reference standard for fusion image and MPS.
Results: Total 144 coronary arteries in 48 patients were analyzed; Fusion image yielded the sensitivity, specificity, negative and positive predictive value for the detection of hemodynamically significant stenosis per coronary artery 82.5%, 79.3%, 76.7% and 84.6%, respectively. Respective values for the MPS were 68.8%, 70.7%, 62.1% and 76.4%. And fusion image also could detect more multi-vessel disease.
Conclusion: Fused three dimensional volume-rendered SPECT/CTA imaging provides intuitive convincing information about hemodynamic relevant lesion and could improved diagnostic accuracy.
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KEYWORD
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SPECT, SPECT/CT, fusion imaging, coronary artery disease
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