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KMID : 1148920100440030177
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Nuclear Medicine and Molecular Imaging
2010 Volume.44 No. 3 p.177 ~ p.184
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18F-FDG PET/CT is Useful for Pretreatment Assessment of the Histopathologic Type of Thymic Epithelial Tumors
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Kim Ji-Young
Kim Hye-Ok
Kim Jae-Seung
Moon Dae-Hyuk
Kim Yong-Hee
Kim Dong-Kwan
Park Seung-II
Park Young-Soo
Ryu Jin-Sook
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Abstract
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Purpose: This study was performed to assess the usefulness of 18F-fluorodeoxyglucose (18F-FDG) positron emission tomography (PET) or PET/computed tomography (CT) for distinguishing thymic epithelial tumors according to World Health Organization (WHO) classifications.
Methods: We analyzed a total of 45 patients (range, 29?75 years of age; mean, 55 years) with pathologically confirmed thymic epithelial tumors who underwent pretreatment 18F-FDG PET or PET/CT between November 2003 and October 2009. The size, visual grading of uptake value, peak standardized uptake value (SUVpeak), uptake pattern, and contour of each tumor, and associated findings on PET or PET/CT, were analyzed relative to the three simplified WHO subgroups: less-invasive thymomas (types A and AB), more-invasive thymomas (types B1, B2, and B3) and thymic carcinomas. We statistically assessed the relationship of 18F-FDG PET or PET/CT findings with these simplified subgroups.
Results: Of the 45 patients, ten had less-invasive thymomas, 23 had more-invasive thymomas, and 12 had thymic carcinomas. The SUVpeak of the less- and more-invasive thymomas were significantly lower than those of thymic carcinomas (p?
Conclusion: The image findings of 18F-FDG PET or PET/CT differed significantly by histologic subgroups. Pre-treatment evaluation with 18F-FDG PET or PET/CT might be helpful in differentiating subgroups of thymic epithelial tumors.
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KEYWORD
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18F-fluorodeoxyglucose, PET, Thymus, Thymoma, Thymic carcinoma
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