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KMID : 1148920120460030201
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Nuclear Medicine and Molecular Imaging
2012 Volume.46 No. 3 p.201 ~ p.206
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Prognostic Significance of Volume-based Metabolic Parameters by 18F-FDG PET/CT in Gallbladder Carcinoma
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Yoo Jang
Choi Joon-Young
Lee Kyu-Taek
Heo Jin-Seok
Park Soo-Bin
Moon Seung-Hwan
Choe Yearn-Seong
Lee Kyung-Han
Kim Byung-Tae
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Abstract
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Purpose: We investigated the prognostic values of volume-based metabolic parameters by 18F-fluorodeoxyglucose (18F-FDG) positron emission tomography (PET)/computed tomography (CT) in gallbladder carcinoma patients and compared them with other prognostic parameters.
Materials and Methods: We enrolled 44 patients, who were initially diagnosed with gallbladder carcinoma and undergoing 18F-FDG PET/CT. Various metabolic volume-based PET parameters of primary tumors, including maximum and average standardized uptake values (SUVmax, SUVavg), metabolic tumor volume (MTV), and total lesion glycolysis (TLG), were measured in gallbladder carcinoma patients using mediastinal blood pool activity as a threshold SUV for determining the tumor boundaries. Overall survival analysis was performed using the Kaplan-Meier method with PET parameters and other clinical variables. For determining independent prognostic factors, Cox proportional hazards regression analysis was performed.
Results: Of the 44 enrolled patients, cancer- or treatment-related death occurred in 30 (68.2 %). The mean clinical follow-up period was 22.2?±?10.4 m (range, 0.6-35.9 m). Univariate analysis demonstrated that clinical or pathologic TNM stage (P?
Conclusions: In gallbladder cancer, TLG of the primary tumor, a volume-based metabolic parameter, is a significant independent prognostic factor for overall survival in conjunction with the clinical or pathological TNM stage.
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KEYWORD
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Gallbladder carcinoma, Prognosis, 18F-FDG, PET/CT, Metabolic tumor volume, Total lesion glycolysis
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