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KMID : 1148920120460030207
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Nuclear Medicine and Molecular Imaging
2012 Volume.46 No. 3 p.207 ~ p.214
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Prognostic value of SUVmax measured by Fluorine-18 Fluorodeoxyglucose Positron Emission Tomography with Computed Tomography in Patients with Pancreatic Cancer
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Hwang Jae-Pil
Lim Il-Han
Chang Kyoung-Jin
Kim Byung-Il
Choi Chang-Woon
Lim Sang-Moo
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Abstract
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Purpose: Recent studies have been conducted on the relationship between fluorodeoxyglucose (FDG) uptake in F-18 FDG PET/CT and prognosis in patients with pancreatic cancer, but these studies have been carried out in small numbers of patients. The aim of this retrospective study was to determine in a large number of patients whether glucose metabolism as assessed by F-18 FDG PET/CT provides prognostic information independent of established prognostic factors in patients with pancreatic cancer.
Methods: We reviewed retrospectively the medical records of 165 patients (men 105, women 60, mean age 67?±?10 years) with a diagnosis of pancreatic cancer that had undergone F-18 FDG PET/CT as part of a pretreatment workup from January 2004 to December 2009. Subsequently, all patients underwent surgery, cyberknife, radiotherapy, and/or chemotherapy. For the analysis, patients were classified by age, demographic data, maximum standardized uptake value (SUVmax), size, location, serum level of CA19-9, type of treatment, and AJCC stage. The relationship between FDG uptake and survival was analyzed using the Kaplan-Meier with log-Rank test and Cox’s proportional-hazard regression methods.
Results: Median survival for all 165 study subjects was 290 days and median SUV by PET/CT was 5.8 (range: 0?25.1). Patients were allocated to high (>?4.1) and low (≤4.1) SUV groups, and median survivals of these patients were 229 days and 610 days, respectively, which were significantly different (p?
Conclusion: The present study shows that SUVmax on F-18 FDG PET/CT can provide a prognostic information in patients with pancreatic cancer.
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KEYWORD
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Survival, FDG, PET/CT, Pancreatic cancer
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