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KMID : 1148920130470010036
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Nuclear Medicine and Molecular Imaging
2013 Volume.47 No. 1 p.36 ~ p.43
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Usefulness of Combined Metabolic?Volumetric Indices of 18F-FDG PET/CT for the Early Prediction of Neoadjuvant Chemotherapy Outcomes in Breast Cancer
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Im Hyung-Jun
Kim Yu-Kyeong
Kim Yong-Il
Lee Jong-Jin
Lee Won-Woo
Kim Sang-Eun
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Abstract
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Purpose: The purpose of this study was to investigate the usefulness of metabolic-volumetric indices of 18F- fluorodeoxy-D-glucose (18F-FDG) positron emission tomography/computed tomography (PET/CT) for the evaluation of neoadjuvant chemotherapy outcomes in breast cancer.
Methods: Twenty-four patients with locally advanced breast cancer were enrolled in the study. They underwent baseline 18F-FDG PET/CT scan and received four or six cycles of neoadjuvant chemotherapy, interim 18F-FDG PET/CT was done after second cycle of chemotherapy. Maximum standardized uptake value (SUVmax), metabolic tumor volume (MTV), and total lesion glycolysis (TLG) of the primary lesions were calculated. Reduction rates of these parameters were obtained between baseline and interim 18F-FDG PET/CT. Chemotherapy outcomes were assessed using tumor size reduction rate and histological grading system (Miller and Payne system). Reduction rates of SUVmax, MTV, and TLG correlated with chemotherapy outcomes.
Results: MTV and TLG reduction rates showed significant correlation with tumor size reduction rate (R?=?0.68, P?=?0.0004; R?=?0.62, P?=?0.002, respectively). However, SUVmax reduction rate showed no significant correlation. MTV and TLG reduction rates were significantly higher in responders than nonresponders, as determined by Miller and Payne system (P?
Conclusion: Changes of metabolic?volumetric indices successfully reflected the neoadjuvant chemotherapy outcomes. MTV and TLG could be robust indices in discriminating pathologic responder as SUVmax, after neoadjuvant chemotherapy.
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KEYWORD
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Breast cancer, Neoadjuvant chemotherapy, Metabolic tumor volume, Total lesion glycolysis, 18F-FDG PET/CT
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