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KMID : 1148920140480030203
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Nuclear Medicine and Molecular Imaging
2014 Volume.48 No. 3 p.203 ~ p.211
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Significance of Salivary Gland Radioiodine Retention on Post-ablation 131I Scintigraphy as a Predictor of Salivary Gland Dysfunction in Patients with Differentiated Thyroid Carcinoma
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Jo Kyung-Sook
An Young-Sil
Lee Su-Jin
Soh Euy-Young
Lee Jeong-Hun
Chung Yoon-Sok
Kim Dae-Jung
Yoon Seok-Ho
Lee Dong-Hyun
Yoon Joon-Kee
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Abstract
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Purpose: We investigated whether 131I whole-body scintigraphy could predict functional changes in salivary glands after radioiodine therapy.
Methods: We evaluated 90 patients who received initial high-dose (≥3.7 GBq) radioiodine therapy after total thyroidectomy. All patients underwent diagnostic (DWS) and post-ablation (TWS) 131I whole-body scintigraphy. Visual assessment of salivary radioiodine retention on DWS and TWS was used to divide the patients into two types of groups: a DWS+ or DWS- group and a TWS+ or TWS- group. Salivary gland scintigraphy was also performed before DWS and at the first follow-up visit. Peak uptake and %washout were calculated in ROIs of each gland. Functional changes (Δuptake or Δwashout) of salivary glands after radioiodine therapy were compared between the two groups.
Results: Both peak uptake and the %washout of the parotid glands were significantly lower after radioiodine therapy (all p values <0.001), whereas only the %washout were significantly reduced in the submandibular glands (all p values <0.05). For the parotid glands, the TWS+ group showed larger Δuptake and Δwashout after radioiodine therapy than did the TWS- group (all p values <0.01). In contrast, the Δuptake and Δwashout of the submandibular glands did not significantly differ between the TWS+ and TWS- groups (all p values >0.05). Likewise, no differences in Δuptake or Δwashout were apparent between the DWS+ and DWS- groups in either the parotid or submandibular glands (all p values >0.05).
Conclusion: Salivary gland radioiodine retention on post-ablation 131I scintigraphy is a good predictor of functional impairment of the parotid glands after high-dose radioiodine therapy.
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KEYWORD
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Radioiodine therapy, Salivary gland dysfunction, Differentiated thyroid cancer, 131I scintigraphy, Salivary gland scintigraphy
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