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KMID : 1148920140480040262
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Nuclear Medicine and Molecular Imaging
2014 Volume.48 No. 4 p.262 ~ p.271
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Tc-99m Hydroxymethylene Diphosphonate (HMDP) Renal Uptake as a Surrogate Marker of Postoperative Impairment of the Glomerular Filtration Rate in Renal Tumor Patients Following Nephron-Sparing Surgery
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Choi Hong-Yoon
Lee Won-Woo
So Young
Ha Seung-Gyun
Byun Seok-Soo
Kim Sang-Eun
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Abstract
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Purpose: We investigated Tc-99m hydroxymethylene diphosphonate (HMDP) scintigraphy findings in renal tumor patients from the perspective of postoperative renal dysfunction following nephron-sparing surgery (NSS).
Methods: Forty-three renal tumor patients (M:F = 28:15, age 53.9?±?12.5 years) who had undergone Tc-99m HMDP scintigraphy after NSS were enrolled. The patients were divided into HMDP+ or HMDP? groups by visual assessment, and the asymmetric index (ASI) was calculated using a region-of-interest analysis. In 16 patients, the total and split glomerular filtration rate (GFR) was assessed using Tc-99m diethylenetriaminepentaacetic acid (DTPA) scintigraphy at baseline and at 3 and 6 months post-NSS.
Results: High Tc-99m HMDP uptake was observed in the operated kidneys, but this did not persist later than 7 days post-NSS. Split GFR of the operated kidneys at baseline (58.5?±?9.3 ml/min) was significantly reduced at 6 months post-NSS (40.1?±?5.9 ml/min, p?
Conclusions: Tc-99m HMDP uptake within 1 week following NSS is a surrogate marker of GFR impairment over 6 months post-NSS.
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KEYWORD
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Tc-99m phosphonate, Scintigraphy, Glomerular filtration rate, Nephrectomy
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