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KMID : 1148920160500020099
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Nuclear Medicine and Molecular Imaging
2016 Volume.50 No. 2 p.99 ~ p.101
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Application of a Small Molecule Radiopharmaceutical Concept to Improve Kinetics
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Jeong Jae-Min
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Abstract
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Recently, large molecules or nanoparticles are actively studied as radiopharmaceuticals. However, their kinetics is problematic because of a slow penetration through the capillaries and slow distribution to the target. To improve the kinetics, a two-step targeting method can be applied by using small molecules and very rapid copper-free click reaction. Although this method might have limitations such as internalization of the first targeted conjugate, it will provide high target-to-non-target ratio imaging of radiopharmaceuticals.
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KEYWORD
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Editorial
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FullTexts / Linksout information
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