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KMID : 1148920160500030261
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Nuclear Medicine and Molecular Imaging
2016 Volume.50 No. 3 p.261 ~ p.265
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Role of 18F-FDG PET-CT in Monitoring the Cyclophosphamide Induced Pulmonary Toxicity in Patients with Breast Cancer ? 2 Case Reports
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Taywade Sameer Kamalakar
Kumar Rakesh
Bhethanabhotla Sainath
Bal Chandrasekhar
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Abstract
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Drug induced pulmonary toxicity is not uncommon with the use of various chemotherapeutic agents. Cyclophosphamide is a widely used chemotherapeutic drug in the treatment of breast cancer. Although rare, lung toxicity has been reported with cyclophosphamide use. Detection of bleomycin induced pulmonary toxicity and pattern of 18F-fluorodeoxyglucose (18F-FDG) uptake in lungs on fluorodeoxyglucose positron emission tomography-computed tomography (18F-FDG PET-CT) has been elicited in literature in relation to lymphoma. However, limited data is available regarding the role of 18F-FDG PET-CT in monitoring drug induced pulmonary toxicity in breast cancer. We here present two cases of cyclophosphamide induced drug toxicity. Interim 18F-FDG PET-CT demonstrated diffusely increased tracer uptake in bilateral lung fields in both these patients. Subsequently there was resolution of lung uptake on 18F-FDG PET-CT scan post completion of chemotherapy. These patients did not develop significant respiratory symptoms during chemotherapy treatment and in follow up.
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KEYWORD
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Carcinoma breast, Cyclophosphamide, Drug induced, 18F-FDG PETCT, Pulmonary toxicity
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