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KMID : 1148920170510030261
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Nuclear Medicine and Molecular Imaging
2017 Volume.51 No. 3 p.261 ~ p.265
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Composite Cutaneous Lymphoma (Iatrogenic Immunodeficiency-Associated Lymphoproliferative Disorder) in a Patient with Rheumatoid Arthritis Treated with Methotrexate: Staging and Evaluation of Response to Therapy with 18F-FDG PET/CT
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Makis William
Ciarallo Anthony
Wang Beatrice
Gonzalez Verdecia Milene
Probst Stephan
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Abstract
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A 67 year old woman with a 10 year history of rheumatoid arthritis (RA) treated with methotrexate and prednisone, presented with a 2 year history of worsening multiple cutaneous plaques of variable appearance. Two distinct skin lesions were biopsied to reveal a composite cutaneous lymphoma, possibly caused by long term methotrexate therapy. An [18F] fluoro-2-deoxy-D-glucose (18F-FDG) positron emission tomography/computed tomography (PET/CT) was performed to stage the malignancy, and was later repeated to evaluate response to chemotherapy, which guided subsequent management. We present the PET/CT imaging findings of this very rare iatrogenic (methotrexate induced) immunodeficiency-associated lymphoproliferative disorder.
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KEYWORD
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Composite lymphoma, Cutaneous lymphoma, Iatrogenic immunodeficiency-associated lymphoproliferative disorder, Methotrexate, PET/CT, Rheumatoid arthritis
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