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KMID : 1148920190530030199
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Nuclear Medicine and Molecular Imaging
2019 Volume.53 No. 3 p.199 ~ p.207
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Lesion-Wise Comparison of Pre-Therapy and Post-Therapy Effective Half-Life of Iodine-131 in Pediatric and Young Adult Patients with Differentiated Thyroid Cancer Undergoing Radioiodine Therapy
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Kumar Praveen
Bal Chandrasekhar
Damle Nishikant Avinash
Ballal Sanjana
Dwivedi S. N.
Agarwala Sandeep
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Abstract
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Purpose: The effective half-life of radioiodine is an important parameter for dosimetry in differentiated thyroid cancer patients, particularly in children. We determined the pre-therapy and post-therapy effective half-life in different types of lesions, i.e., remnant, node, or lung metastases.
Methods: Of 84 patients recruited, 27 were
Results: The post-therapy effective half-life was found to be lesser than pre-therapy effective half-life in all types of lesions and in all groups. Median effective half-life was found maximum in intact lobe, minimum in the lung, and intermediate in remnant and nodes. In the assessment of all lesions together, pre- and post-therapy median and interquartile range (IQR) effective half-life were 59.8 (37?112) h and 48.6 (35.2?70.8) h (p?
Conclusions: There was a significant difference in pre-therapy and post-therapy effective half-life in all types of lesions. These results may have implications in calculating the correct therapeutic dose in children and in young adults.
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KEYWORD
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Effective half-life, Thyroid cancer, Pediatric, Radioiodine therapy, Pre-therapy, Post-therapy
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