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KMID : 1148920190530030216
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Nuclear Medicine and Molecular Imaging
2019 Volume.53 No. 3 p.216 ~ p.222
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How Do the More Recent Reconstruction Algorithms Affect the Interpretation Criteria of PET/CT Images?
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Matti Antonella
Lima Giacomo Maria
Pettinato Cinzia
Pietrobon Francesca
Martinelli Felice
Fanti Stefano
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Abstract
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Purpose: Recently, a new Bayesian Penalized Likelihood (BPL) Reconstruction Algorithm was introduced by GE Healthcare, Q.Clear; it promises to provide better PET image resolution compared to the widely used Ordered Subset Expectation Maximization (OSEM). The aim of this study is to compare the performance of these two algorithms on several types of findings, in terms of image quality, lesion detectability, sensitivity, and specificity.
Methods: Between September 6th 2017 and July 31st 2018, 663 whole body 18F-FDG PET/CT scans were performed at the Nuclear Medicine Department of S. Martino Hospital (Belluno, Italy). Based on the availability of clinical/radiological follow-up data, 240 scans were retrospectively reviewed. For each scan, a hypermetabolic finding was selected, reporting both for OSEM and Q.Clear: SUVmax and SUVmean values of the finding, the liver and the background close to the finding; size of the finding; percentage variations of SUVmax and SUVmean. Each finding was subsequently correlated with clinical and radiological follow-up, to define its benign/malignant nature.
Results: Overall, Q.Clear improved the SUV values in each scan, especially in small findings (
Conclusions: Q.Clear is an iterative algorithm that improves significantly the quality of PET images compared to OSEM, increasing the SUVmax of findings (in particular for small findings) and the signal-to-noise ratio. However, due to the intrinsic characteristics of this algorithm, it will be necessary to adapt and/or modify the current interpretative criteria based of quantitative evaluation, to avoid an overestimation of the disease burden.
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KEYWORD
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Q.Clear, OSEM, 18FDG-PET, Reconstruction algorithm, BPL reconstruction algorithm, PET/CT
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