|
KMID : 1148920190530050334
|
|
Nuclear Medicine and Molecular Imaging
2019 Volume.53 No. 5 p.334 ~ p.339
|
|
|
Cerebral Amyloid Quantification in Cognitively Normal Korean Adults Using F-18 Florbetaben PET
|
|
Jeong Ji-Eun
Jeong Young-Jin
Park Kyung-Won
Kang Do-Young
|
|
|
Abstract
|
|
|
Purpose: To investigate regional cerebral amyloid beta retention in cognitively normal Korean adults using F-18 florbetaben (FBB).
Methods: We prospectively analyzed F-18 FBB positron emission tomography (PET)/CT scans of 30 cognitively healthy adults (age range, 50?70 years) using automated quantification. The standardized uptake value ratios (SUVRs) of F-18 FBB were calculated for predefined regions by normalizing the regional count with cerebellar cortex.
Results: The distribution of amyloid beta for each brain region revealed no age-related trends (p >?0.05). From all subjects, mean SUVR of amyloid deposit was 1.30?±?0.18. The right parietal lobe showed the highest SUVR value (1.46?±?0.23), whereas the right frontal lobe and left precuneus showed the lowest SUVR (1.23?±?0.25).
Conclusions: We provide reference values of normative data obtained from healthy elderly Koreans and suggest its use for accurate diagnosis of patients with Alzheimer’s disease.
|
|
|
KEYWORD
|
|
|
Alzheimer’s disease, F-18 florbetaben, Healthy, SUVR
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
  
|