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KMID : 1148920220560020102
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Nuclear Medicine and Molecular Imaging
2022 Volume.56 No. 2 p.102 ~ p.104
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[68 Ga]Ga-PSMA-11 Small Bowel Uptake in Crohn’s Disease: Revisiting the “Non-specificity” of PSMA Ligands
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Chandekar Kunal Ramesh
Tanigassalam Sindhu
Kavanal Anwin Joseph
Singh Harmandeep
Bhattacharya Anish
Mavuduru Ravimohan Suryanarayan
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Abstract
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The rapidly evolving clinical utility of prostate-specific membrane antigen (PSMA) PET/CT as an imaging modality for prostate cancer (PCa) has brought to the forefront a multitude of non-prostatic diseases also exhibiting PSMA radioligand uptake. We report a case of a 71-year-old male with PCa who underwent PSMA PET/CT for recurrence evaluation. The scan demonstrated [68 Ga]Ga-PSMA-11 uptake in the distal ileum. Retrospective enquiry revealed that the patient was a known case of Crohn’s disease. This case highlights an uncommon finding of PSMA radioligand uptake in the distal small bowel (non-prostatic benign pathological uptake) in a patient with known Crohn’s disease, which may be misinterpreted in the evaluation of PCa.
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KEYWORD
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Prostate-specific membrane antigen (PSMA), Prostate cancer, PET/CT, Inflammatory bowel disease (IBD), Crohn’s disease
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