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KMID : 1148920230570030117
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Nuclear Medicine and Molecular Imaging
2023 Volume.57 No. 3 p.117 ~ p.125
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The Presence of Residual Vascular and Adipose Tissue Inflammation on 18F-FDG PET in Patients with Chronic Coronary Artery Disease
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Sini Toivonen
Miia Lehtinen
Peter Raivio
Juha Sinisalo
Antti Loimaala
Valtteri Uusitalo
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Abstract
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Purpose : We evaluated the residual vascular and adipose tissue inflammation in patients with chronic coronary artery disease (CAD) using positron emission tomography (PET).
Methods : Our study population consisted of 98 patients with known CAD and 94 control subjects who had undergone 18F-fluorodeoxyglucose (18F-FDG) PET due to non-cardiac reasons. Aortic root and vena cava superior 18F-FDG uptake were measured to obtain the aortic root target-to-background ratio (TBR). In addition, adipose tissue PET measurements were done in pericoronary, epicardial, subcutaneous, and thoracic adipose tissue. Adipose tissue TBR was calculated using the left atrium as a reference region. Data are presented as mean?±?standard deviation or as median (interquartile range).
Results : The aortic root TBR was higher in CAD patients compared to control subjects, 1.68 (1.55?1.81) vs. 1.53 (1.43?1.64), p??0.05).
Conclusion : Patients with a chronic CAD had a higher aortic root and subcutaneous adipose tissue 18F-FDG uptake compared to control patients, which suggests residual inflammatory risk.
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KEYWORD
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Coronary artery disease, Infammation, Positron emission tomography
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