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KMID : 1148920230570030137
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Nuclear Medicine and Molecular Imaging
2023 Volume.57 No. 3 p.137 ~ p.144
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Algorithm for Reducing Overall Biological Detriment Caused by PET/CT: an Age-Based Study
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Marco Spadafora
Pasqualina Sannino
Luigi Mansi
Ciro Mainolfi
Rosario Capasso
Eugenio Di Giorgio
Salvatore Fiordoro
Serena Imbimbo
Filomena Masone
Laura Evangelista
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Abstract
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Purpose : This study is to use a simple algorithm based on patient’s age to reduce the overall biological detriment associated with PET/CT.
Materials and Methods : A total of 421 consecutive patients (mean age 64 ± 14 years) undergoing PET for various clinical indications were enrolled. For each scan, effective dose (ED in mSv) and additional cancer risk (ACR) were computed both in a reference condition (REF) and after applying an original algorithm (ALGO). The ALGO modified the mean dose of FDG and the PET scan time parameters; indeed, a lower dose and a longer scan time were reported in the younger, while a higher dose and a shorter scan time in the older patients. Moreover, patients were classified by age bracket (18?29, 30?60, and 61?90 years).
Results : The ED was 4.57 ± 0.92 mSv in the REF condition. The ACR were 0.020 ± 0.016 and 0.0187 ± 0.013, respectively, in REF and ALGO. The ACR for the REF and ALGO conditions were significantly reduced in males and females, although it was more evident in the latter gender (all p < 0.0001). Finally, the ACR significantly reduced from the REF condition to ALGO in all three age brackets (all p < 0.0001).
Conclusion : Implementation of ALGO protocols in PET can reduce the overall ACR, mainly in young and female patients.
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KEYWORD
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PET, FDG, Radiation risk, Efective dose, Additional cancer risk
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