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KMID : 1148920230570030159
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Nuclear Medicine and Molecular Imaging
2023 Volume.57 No. 3 p.159 ~ p.161
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Hot Embolus Artifact Mimicking Disease Progression in Post-therapy 177Lu-DOTATATE Scan: Incremental Value of SPECT/CT
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Piyush Aggarwal
Anupriya Anwariya
Anwin Joseph Kavanal
Ashwani Sood
Santosh Ranjan Jena
Bhagwant Rai Mittal
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Abstract
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Peptide receptor radionuclide therapy (PRRT) has become an established treatment for patients with inoperable and/or metastatic, well-differentiated neuroendocrine tumors with overexpression of somatostatin receptor type 2 (SSTR-2). The post-therapy 177Lu-DOTATATE whole-body scan not only assesses the biodistribution of the lesions seen on pre-therapy 68 Ga-SSTR PET/CT scan but also provides a quick assessment of disease status and dosimetry during treatment. Like any other radionuclide scan, the whole-body 177Lu-DOTATATE scan may also show abnormal radiotracer uptake, which may require further imaging to establish its exact etiology. Though radiotracer emboli mimicking focal pulmonary lesions have been described with 18F-FDG and 68 Ga-DOTANOC PET/CT scans, similar artifacts with post-therapy 177Lu-DOTATATE scans have not been described. Herein, we report two cases of hot emboli in the post-therapy 177Lu-DOTATATE scans.
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KEYWORD
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Artifacts, Neuroendocrine tumors, 177Lu-DOTATATE, Whole body imaging
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