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KMID : 1148920230570060257
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Nuclear Medicine and Molecular Imaging
2023 Volume.57 No. 6 p.257 ~ p.264
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Comparison of Prognostic Value Between Stimulated and Nonstimulated Thyroglobulins in Differentiated Thyroid Cancer: A Retrospective Study
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Son Jun-Ik
Hong Chae-Moon
Kim Do-Hoon
Jeong Shin-Young
Lee Sang-Woo
Lee Jae-Tae
Ahn Byeong-Cheol
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Abstract
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Purpose : The growing incidence of differentiated thyroid cancer (DTC) demands dependable prognostic factors to guide follow-up and treatment plans. This study investigated the prognostic value of response to therapy (RTT) assessment using TSH stimulated-thyroglobulin (sti-Tg) and nonstimulated-thyroglobulin (nonsti-Tg) and evaluates whether RTT using nonsti-Tg (nonstiRTT) can replace RTT using sti-Tg (stiRTT) in clinical practice to improve patients’ quality of life during assessment.
Methods : We enrolled 419 DTC patients who underwent total thyroidectomy, radioactive iodine (RAI) therapy, and Tg assessment. Patients with structural incomplete responses were excluded. Initial RTT assessments based on the 2015 American Thyroid Association guidelines (excellent response; ER, indeterminate response, biochemical incomplete response) were performed 6?24 months after RAI therapy. The second RTT assessments were performed 6?24 months after the first assessment. Statistical analysis for recurrence-free survival (RFS) was done with the log-rank test for stiRTT and nonstiRTT.
Results : Although initial stiRTT and nonstiRTT were significant predictors for RFS (p?
Conclusion : The prognostic power of stiRTT surpasses that of nonstiRTT in both the initial and second RTT assessment. Nevertheless, among patients classified as ER on initial stiRTT, a second stiRTT may not be required for those classified as ER on the second nonstiRTT.
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KEYWORD
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Response to therapy, Thyroid cancer, Thyroglobulin, Stimulated Tg, Nonstimulated Tg
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