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KMID : 1148920230570060298
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Nuclear Medicine and Molecular Imaging
2023 Volume.57 No. 6 p.298 ~ p.300
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68Ga-PSMA-11 PET/CT in Bilateral Clear Cell Renal Cell Carcinoma: an Intra-patient Comparison Between High and Low Grade Tumors
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Luca Urso
Giovanni Christian Rocca
Grazia Maria Conti
Alessandro Colella
Alberto Nieri
Corrado Cittanti
Carmelo Ippolito
Mirco Bartolomei
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Abstract
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Recent studies have outlined the emerging role of 68Ga-PSMA-11 PET/CT in the diagnostic algorithm of clear cell renal cell carcinoma (ccRCC). We report a unique intra-patient comparison of bilateral primary ccRCC imaged with 68Ga-PSMA-11 PET/CT. Although both tumors resulted 68Ga-PSMA-11 avid, we found a remarkable discrepancy in uptake intensity between the high grade and the low grade ccRCC. This case confirms previous evidence reporting that SUVmax on 68Ga-PSMA-11 PET/CT could be used to discriminate aggressive high grade from more indolent low grade ccRCC, due to their different endothelial expression of PSMA.
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KEYWORD
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68Ga-PSMA PET/CT, PSMA PET, ccRCC, Renal cell carcinoma, Clear cell renal cell carcinoma
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