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KMID : 1150720190080010057
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Integrative Medicine Research
2019 Volume.8 No. 1 p.57 ~ p.61
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Efficacy of curcumin/turmeric on liver enzymes in patients with non-alcoholic fatty liver disease: A systematic review of randomized controlled trials
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Mansour-Ghanaei Fariborz
Pourmasoumi Makan
Hadi Amir
Joukar Farahnaz
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Abstract
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Background: Several studies reported that curcumin supplementation could improve non-alcoholic fatty liver disease (NAFLD). The aim of this study was to evaluate the efficacy of curcumin/turmeric supplementation on liver enzymes in patients with NAFLD.
Methods: PubMed, Scopus, Web of Science and Google Scholar were systematically searched until December 2017. We included randomized controlled trials (RCTs) which examined effect of curcumin/turmeric supplementation on NAFLD in adult participants. Main outcome was alanine aminotransferase (ALT) and aspartate aminotransferase (AST). Potential risks of bias (ROB) were assessed by using Cochrane ROB tool.
Results: All included studies showed low ROB in most of item of Cochrane ROB tool. Meta-analysis of 4 randomized controlled trials including 228 subjects showed a trend toward significant reduction of ALT blood concentrations in subgroup with ≥1000?mg/day curcumin supplementation (?11.36 IU/L, 95% CI: ?22.75 to 0.02; I2:51%). Meta-analysis showed a significant reduction of AST in studies with 8-weeks administration (?9.22?IU/L, 95% CI: ?12.77 to ?5.67; I2: 49%).
Conclusion: This review suggests that curcumin/turmeric might have a favorable effect on NAFLD in higher dosage. Further high-quality studies with large-scale and higher dosage are warranted.
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KEYWORD
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Curcumin, Non-alcoholic fatty liver, Alanine transaminase, Aspartate aminotransferases, Meta-analysis
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