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KMID : 1151620160010010023
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Journal of Retina
2016 Volume.1 No. 1 p.23 ~ p.28
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Comparative Study of Subjects with Chronic Central Serous Chorioretinopathy Undergoing Half-Dose or Time-Reduced Photodynamic Therapy
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Kim Yun-Taek
Kang Se-Woong
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Abstract
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Purpose: To compare the clinical outcomes of reduced fluence (time-reduced) photodynamic therapy (PDT) and half-dose PDT in treating chronic central serous chorioretinopathy (CSC).
Methods: Medical records of patients who underwent half-dose or reduced fluence PDT for chronic CSC were reviewed. The clinical outcomes of 34 eyes that underwent half-dose PDT and 39 eyes that underwent reduced fluence PDT were compared.
Results: Six months after treatment, complete absorption of subretinal fluid was observed in 29 of 34 eyes (85.3%) in the half-dose PDT group and 36 of 39 eyes (92.3%) in the reduced fluence PDT group (p = 0.46). Twenty-one of 34 (61.8%) eyes in the half-dose PDT group and 27 of 39 (69.2%) eyes in the reduced fluence PDT group achieved visual improvement of more than one line in the Snellen chart (p = 0.62). Focal retinal pigment epithelium degeneration after treatment was noted in 7 of 27 eyes (25.9%) in the half-dose PDT group and 10 of 30 (33.3%) eyes in the reduced fluence PDT group (p = 0.58).
Conclusions: Reduced fluence PDT showed a favorable outcome, similar to that of half-dose PDT, in treating chronic CSC. Because of its convenient preparation and application, reduced fluence (low-fluence) PDT might be an alternative treatment modality in treating chronic CSC.
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KEYWORD
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Central serous chorioretinopathy, Photodynamic therapy, Verteporfin
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