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KMID : 1151620170020010045
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Journal of Retina
2017 Volume.2 No. 1 p.45 ~ p.50
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Presumed Ocular Relapse of Diffuse Large B Cell Uterine Lymphoma Presenting Only as Vitritis after Continuous and Complete Remission
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Lee Jin-Hae
Baek Ji-Won
Lee Won-Ki
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Abstract
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Purpose: To report an ocular relapse of diffuse large B cell uterine lymphoma.
Case summary: A 51-year-old woman with diffuse large B cell uterine lymphoma reached and maintained complete remission for four consecutive years at six re-staging evaluations after six cycles of cyclophosphamide, hydroxyl-daunorubicin, oncovin, and prednisone chemotherapy. Late ocular relapse of diffuse large B cell lymphoma may simply present as cells in the vitreous cavity without any systemic involvement. Diagnostic vitrectomy was performed, and the cytopathologic exam showed monoclonal B cell origin lymphoma. The patient was given a repeat course of intravitreal methotrexate injections and six cycles of high-dose methotrexate and Ara-C intravenously. Despite the chemotherapy, brain involvement was detected 26 months after the diagnosis. However, the patient remains alive after 48 months.
Conclusions: In selected patients with intraocular lymphoma, having a high degree of clinical suspicion is the most important factor required to make the diagnosis; diagnostic vitrectomy is useful for both diagnostic and therapeutic purposes.
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KEYWORD
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Diagnostic vitrectomy, Diffuse large B cell lymphoma, Intraocular lymphoma, Intravitreal methotrexate injection, Uterine lymphoma
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