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KMID : 1151620170020020060
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Journal of Retina
2017 Volume.2 No. 2 p.60 ~ p.67
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Subretinal Tenecteplase Injection for Submacular Hemorrhage in Age-related Macular Degeneration
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Kim Yang-Jae
Kim Ju-Young
Seong San
You Yong-Sung
Kwon Oh-Woong
Kim Soon-Hyun
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Abstract
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Purpose: To investigate the efficacy and safety of a surgical procedure with subretinal tenecteplase (TNK) injection for displacement of thick submacular hemorrhage in patients with age-related macular degeneration (AMD).
Methods: A retrospective, non-comparative, interventional case study was conducted. Medical records of patients with submacular hemorrhage secondary to AMD who underwent subretinal TNK injection were reviewed. Best-corrected visual acuity (BCVA) and spectral domain optical coherence tomography (SD-OCT) at baseline, 1 month, 3 months, and final follow-up after initial treatment were measured. Postoperative complications were identified.
Results: Eleven eyes of eleven patients who underwent subretinal TNK injection for submacular hemorrhage were included. Mean BCVA at baseline was 1.85 ± 0.90 logarithm of the minimum angle of resolution (logMAR), which improved to 1.17 ± 0.63 logMAR at 3 month follow-up and 0.94 ± 0.58 logMAR at final follow-up (p = 0.011). SD-OCT results, including central foveal thickness (495.7 ± 410.7 μm → 230.5 ± 166.4 μm) and submacular hemorrhage thickness (263.3 ± 196.0 μm → 0 μm), significantly improved (p = 0.028). Complications included retinal detachment (n = 2), epiretinal membrane (n = 1), and vitreous hemorrhage (n = 1).
Conclusions: Vitrectomy with subretinal TNK injection may be a good treatment option for displacement of submacular hemorrhage leading to functional and anatomical improvement.
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KEYWORD
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Age-related macular degeneration, Submacular hemorrhage, Subretinal injection, Tenecteplase (TNK)
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