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KMID : 1151620170020020097
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Journal of Retina
2017 Volume.2 No. 2 p.97 ~ p.100
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Cytomegalovirus Retinitis in Patients with Diffuse Large B-cell Lymphoma
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Kang Hae-Min
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Abstract
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Purpose: To report two cases of cytomegalovirus (CMV) retinitis in patients with diffuse large B cell lymphoma (DLBCL).
Case summary: A 59-year-old man (patient 1) visited our ophthalmology clinic due to decreased vision in the left eye. The patient had a history of right nephrectomy due to renal cell tumor, which showed complete remission. Best-corrected visual acuity (BCVA) of the left eye was 20/100 according to the Snellen visual acuity chart. Fundus examination revealed yellowish retinal infiltration with retinal hemorrhages, and diagnostic vitrectomy confirmed CMV retinitis. Further systemic evaluation indicated pancytopenia and bone marrow suppression. Positron emission tomography-computed tomography imaging suggested malignant lymphoma, and subsequent biopsy of lymph nodes confirmed DLBCL. In the second case, a 55-year-old woman (patient 2) presented with a sudden decrease in vision in the left eye during systemic chemotherapy for DLBCL. BCVA in the left eye was 20/125 by Snellen visual acuity chart, and the fundus demonstrated diffuse yellowish retinal infiltration with some grainy opacification. After a diagnosis of CMV retinitis, ganciclovir was administered to both patients, leading to improvement of retinal lesions.
Conclusions: CMV retinitis can occur in patients with DLBCL; thus, when patients with DLBCL complain of visual deterioration, CMV retinitis should be suspected.
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KEYWORD
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Cytomgalovirus (CMV), CMV retinitis, Diffuse large B-cell lymphoma
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