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KMID : 1151620190040020107
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Journal of Retina
2019 Volume.4 No. 2 p.107 ~ p.110
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Paclitaxel-associated Retinopathy in a Female Patient with Breast Cancer
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Kang Hae-Min
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Abstract
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Purpose: To report a case of paclitaxel-associated retinopathy in a 53-year-old female patient with breast cancer, and describe the treatment response to intravitreal bevacizumab injection
Case summary: A 53-year-old female patient visited our Ophthalmology Clinic with a complaint of visual deterioration in both eyes. She had undergone paclitaxel chemotherapy for breast cancer with multiple metastases. Her ophthalmologic history included visual acuity 20/30 in each eye and normal ophthalmologic findings 2 years prior to visual deterioration. At the time of examination, her vision was 20/50 in each eye, and fundus examination showed macular thickening in both eyes. Fluorescein angiography showed faint petalloid dye pooling at the fovea, and spectral domain optical coherence tomography showed intraretinal cysts with macular thickening in each eye. Fundus autofluorescence images showed hypo-autofluorescent petalloid patterns involving the fovea in both eyes. She was diagnosed with paclitaxel-associated retinopathy, but the oncologist refused to stop paclitaxel chemotherapy. We performed intravitreal bevacizumab injection in each eye, which did not result in improvement of macular edema
Conclusions: We report a case of paclitaxel-associated retinopathy that presented with a form of cystoid macular edema, and that did not respond to intravitreal bevacizumab injection. If a patient undergoing paclitaxel chemotherapy complains of visual deterioration, further ophthalmologic evaluation is recommended.
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KEYWORD
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Breast cancer, Macular edema, Paclitaxel
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