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KMID : 1151620210060010034
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Journal of Retina
2021 Volume.6 No. 1 p.34 ~ p.40
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Short-term Efficacy of Intravitreal Aflibercept Therapy for Diabetic Macular Edema
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Hwang Jae-Hyeong
Park Sae-Mi
Kim Chul-Gu
Kim Jong-Woo
Kim Jae-Hui
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Abstract
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Purpose: To evaluate short-term clinical outcomes of patients with diabetic macular edema (DME) who received intravitreal aflibercept injection.
Methods: Retrospective review of medical records was performed for 28 eyes with DME that received aflibercept injection. The best-corrected visual acuity (BCVA) and central macular thickness (CMT) before injection were compared with those at 1 month and 2-3 months after injection. In addition, the factors associated with degree of improvement in BCVA after treatment were analyzed.
Results: Mean BCVA was significantly improved from logMAR 0.61 ± 0.31 before injection to 0.45 ± 0.25 (p = 0.001) after 1 month and to 0.51 ± 0.28 (p = 0.003) after 2-3 months. Mean CMT was significantly decreased from 553.8 ± 144.3 μm before injection to 331.9 ± 76.5 μm (p < 0.001) after 1 month and to 388.2 ± 125.4 μm (p < 0.001) after 2-3 months. Poorer BCVA and greater CMT before injection were associated with greater visual improvement during 1 month after injection.
Conclusions: These results suggest that marked visual improvement and CMT reduction occur in DME patients after aflibercept injection.
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KEYWORD
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Diabetic retinopathy, Macular edema, Outcome, Visual acuity
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