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KMID : 1160220010290030170
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Mycobiology
2001 Volume.29 No. 3 p.170 ~ p.172
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Cytotoxicity of Paecilomyces tenuipes Against Human Carcinoma Cells, HepG2 and MCF-7 In Vitro
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Shim Joong-Sup
Chang Hae-Ryong
Min Eung-Gi
Kim Yong-Hae
Han Yeong-Hwan
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Abstract
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The methanolic extract of fruiting body of Paecilomyces tenuipes DGUM 32001 showed significant cytotoxicity against human cancer cells: HepG2 and MCF-7. The methanolic extract was further fractionated with organic solvents such as chloroform and ethyl acetate in that order. Among the fractions tested, the ethyl acetate fraction showed the highest cytotoxicity against the carcinoma tested. The IC50 values of ethyl acetate fraction against HepG and MCF-7 were 40 and 9.6 μg/ml respectively.
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KEYWORD
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Cytotoxicity, Fruiting body, Paecilomyces tenuipes
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