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KMID : 1160220060340040230
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Mycobiology
2006 Volume.34 No. 4 p.230 ~ p.235
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Antitumor and Antioxidant Activities of the Extracts from Fruiting Body of Phellinus linteus
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Lee June-Woo
Baek Seong-Jin
Bae Woo-Chul
Park Jeong-Min
Kim Yong-Seok
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Abstract
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Fruiting bodies of Phellinus linteus were extracted by hot water and alkali methods. Sugar contents of PL-H (hot water extract) and PL-A (alkali water extract) were 81.1%, 37.4% and protein contents were 6.2%, 21.8%, respectively. Amino acid pattern showed that two extracts contained large amount of aspartic acid and alanine. Two extracts showed characteristic IR absorption pattern for glycosidic bond at 890 cm?1. PL-H was divided two fractions by gel filtration chromatography and the molecular weights of each fraction were estimated to be about 10 kD and 225 kD, respectively and also PL-A was estimated 10 kD. Two extracts showed strong antitumor, immunomodulating and antioxidant activities, and were compared with commercialized glycopeptide anticancer drugs.
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KEYWORD
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Antioxidant, Antitumor, Immunostimulation, Phellinus linteus, Polysaccharide
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