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KMID : 1160220080360030195
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Mycobiology
2008 Volume.36 No. 3 p.195 ~ p.197
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Screening and Optimal Extraction of a New Antidementia β-Secretase Inhibitor-Containing Mushroom
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Seo Dong-Soo
Lee Eun-Na
Seo Geon-Sik
Lee Jong-Soo
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Abstract
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To produce a potent antidementia β-secretase inhibitor from a mushroom, the β-secretase inhibitory activities of various mushroom extracts were determined. Methanol extracts of Lentinula edodes exhibited the highest inhibitory activity (40.1%). The inhibitor was maximally extracted when a fruiting body of L. edodes was treated with 50% methanol at 40oC for 24 h.
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KEYWORD
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Antidementia, BACE1, β-Secretase inhibitor, Lentinula edodes
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