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KMID : 1160220090370020128
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Mycobiology
2009 Volume.37 No. 2 p.128 ~ p.132
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Antitumor Effects and Immunomodulating Activities of Phellinus linteus Extract in a CT-26 Cell-Injected Colon Cancer Mouse Model
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Yang Byung-Keun
Hwang Seung-Lark
Yun Ik-Jin
Do Eun-Ju
Lee Won-Ha
Jung Young-Mi
Hong Sung-Chang
Park Dong-Chan
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Abstract
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The antitumor effects of Phellinus linteus extract (Keumsa Linteusan) were investigated in a CT-26 cell-injected colon cancer mouse model. When administered orally (250~1,000 mg/kg body weight), Keumsa Linteusan significantly inhibited the growth of solid colon cancer. The highest dose was highly effective, reducing tumor formation by 26% compared with the control group. The anticomplementary activity of Keumsa Linteusan increased in a dose-dependent manner. Lysosomal enzyme activity of macrophages was increased by 2-fold (100 μg/ml) compared with the control group. Keumsa Linteusan can be regarded as a potent enhancer of the innate immune response, and can be considered as a very promising candidate for antitumor action.
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KEYWORD
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Anticomplementary, Antitumor, Colon cancer, Keumsa Linteusan, Macrophage lysosomal enzyme, Mouse model, Phellinus linteus
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