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KMID : 1160220100380010052
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Mycobiology
2010 Volume.38 No. 1 p.52 ~ p.57
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Extraction and Characteristics of Anti-obesity Lipase Inhibitor from Phellinus linteus
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Lee Jong-Kug
Jang Jeong-Hoon
Lee Jong-Tae
Lee Jong-Soo
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Abstract
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To develop a potent anti-obesity lipase inhibitor from mushroom, the lipase inhibitory activities of various mushroom extracts were determined. Methanol extracts from Phellinus linteus fruiting body exhibited the highest lipase inhibitory activity (72.8%). The inhibitor was maximally extracted by treatment of a P. linteus fruiting body with 80% methanol at 40oC for 24 hr. After partial purification by systematic solvent extraction, the inhibitor was stable in the range of 40~80oC and pH 2.0~9.0. In addition to lipase inhibitory activity, the inhibitor showed 59.4% of superoxide dismutase-like activity and 56.3%of acetylcholinesterase inhibitory activity.
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KEYWORD
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Anti-obesity, Lipase inhibitor, Phellinus linteus
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