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KMID : 1160220100380030206
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Mycobiology
2010 Volume.38 No. 3 p.206 ~ p.209
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Production of Antihypertensive Angiotensin I-Converting Enzyme Inhibitor- Enriched Edible Yeast Using Gugija (Lycium chinesis Mill)
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Kim Ran
Jang Jeong-Hoon
Park Won-Jong
Kim Ha-Kun
Kwak Hahn-Shik
Lee Jong-Soo
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Abstract
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To produce bioactive compound enriched yeast using medicinal Gugiga (Lycium chinensis Mill), several edible Saccharomyces species were cultured in Gugija extracts added yeast extract, peptone and dextrose medium (GE - YEPD medium) at 30oC for 24 hr, and their growth were determined. Growth of Saccharomyces cerevisiae K-7 and Sacchromyces cerevisiae ACTC 7904 were better than those of the other yeasts. Two yeasts were selected and then determined their some physiological functionalities after cultivated the yeasts in the GE - YEPD medium and compared those grown on YEPD medium. Antihypertensive angiotensin I-converting enzyme (ACE) inhibitory activity of S. cerevisiae K-7 grown on GE - YEPD medium was about 20% higher than that grown on YEPD medium. Superoxide dismutase-like activity of S. cerevisiae ACTC 7904was also about 12% more high. However, the other physiological functionalities were almost same or lower. Optimal addition concentration of Gugija extract was 10%, and maximally growth and ACE inhibitory activity of S. cerevisiae K-7 were shown when the strain was cultured in 10% Gugija extracts containing YEPD medium at 30oC for 12 hr.
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KEYWORD
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Antihypertensive ACE inhibitory activity, Gugija (Lycium chinesis Mill) extract, Saccharomyces cerevisiae
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