KMID : 1160220110390040283
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Mycobiology 2011 Volume.39 No. 4 p.283 ~ p.289
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Appraisal of Antihyperlipidemic Activities of Lentinus lepideus in Hypercholesterolemic Rats
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Yoon Ki-Nam
Lee Jae-Seong Kim Hye-Young Lee Kyung-Rim Shin Pyung-Gyun Cheong Jong-Chun Yoo Young-Bok Alam Nuhu Ha Tai-Moon Lee Tae-Soo
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Abstract
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The wild edible mushroom, Lentinus lepideus has recently been cultivated for commercial use in Korea. While the mushroom has been widely used for nutritional and medicinal purposes, the possible anti-hyperlipidemic action is unclear. The effects of dietary L. lepideus on plasma and feces biochemical and on the liver histological status were investigated in hypercholesterolemic rats. Six-wk-old female Sprague-Dawley albino rats were divided into three groups of 10 rats each. Biochemical and histological examinations were performed. A diet containing 5% L. lepideus fruiting bodies reduced plasma total cholesterol, triglyceride, low-density lipoprotein, total lipid, phospholipids, and the ratio of low-density to high-density lipoprotein. Body weight was reduced. The diet did not adversely affect plasma biochemical and enzyme profiles. L. lepideus reduced significantly plasma ¥â- and pre-¥â-lipoprotein, while ¥á-lipoprotein content was increased. A histological study of hepatic cells by conventional hematoxylin-eosin and oil red O staining revealed normal findings for mushroom-fed hypercholesterolemic rats. The present study suggests that a diet supplemented with L. lepideus can provide health benefits by acting on the atherogenic lipid profile in hypercholesterolemic rats.
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KEYWORD
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Agarose gel electrophoresis, Antihyperlipidemic, Atherogenic lipid profile, Histopathology, Hypercholesterolemic rats, Lentinus lepideus
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