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KMID : 1160220140420020152
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Mycobiology
2014 Volume.42 No. 2 p.152 ~ p.157
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A Ferroxidase, Cfo1, Regulates Diverse Environmental Stress Responses of Cryptococcus neoformans through the HOG Pathway
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Lee Kyung-Tae
Lee Jang-Won
Lee Do-Hyun
Jung Won-Hee
Bahn Yong-Sun
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Abstract
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The iron uptake and utilization pathways play a critical role in allowing human pathogens, including Cryptococcusneoformans, the causative agent of fatal meningoencephalitis, to survive within the mammalian body by competing with the hostfor iron. Here we show that the iron regulon is also required for diverse environmental stress responses and that in C. neoformans, it is regulated by the high-osmolarity glycerol response (HOG) pathway. Between CFO1 and CFO2, two ferroxidasegenes in the iron regulon, CFO1 but not CFO2 was induced during oxidative and osmotic stress. Interestingly, we found that theHOG pathway repressed basal expression of both CFO1 and CFO2. Furthermore, when the HOG pathway was blocked, CFO2also responded to oxidative and osmotic stress and the response of CFO1 was increased. We also established that CFO1 plays amajor role in responding and adapting to diverse environmental stresses, including oxidative and genotoxic damage, osmoticfluctuations, heavy metal stress, and stress induced by cell membrane destabilizers. Therefore, our findings indicate that in C. neoformans, the iron uptake and utilization pathways are not only required for iron acquisition and survival, but also play asignificant role in the environmental stress response through crosstalk with the HOG pathway.
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KEYWORD
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Cfo1, Cfo2, Cryptococcus neoformans, Hog1, Iron
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