|
KMID : 1160220140420020185
|
|
Mycobiology
2014 Volume.42 No. 2 p.185 ~ p.188
|
|
|
Lipoxygenase Inhibitory Activity of Korean Indigenous Mushroom Extracts and Isolation of an Active Compound from Phellinus baumii
|
|
Lee Seung-Woong
Song Ja-Gyeong
Hwang Byung-Soon
Kim Dae-Won
Lee Yoon-Ju
Woo E-Eum
Kim Ji-Yul
Lee In-Kyoung
Yun Bong-Sik
|
|
|
Abstract
|
|
|
|
We investigated a total of 335 samples of Korean native mushroom extracts as part of our lipoxygenase (LOX) inhibitorscreening program. Among the mushroom-methanolic extracts we investigated, 35 exhibited an inhibitory activity greater than30% against LOX at a concentration of 100 μg/mL. Especially, Collybia maculata, Tylopilus neofelleus, Strobilomyces confusus,Phellinus gilvus, P. linteus, P. baumii, and Inonotus mikadoi exhibited relatively potent LOX inhibitory activities of 73.3%, 51.6%,52.4%, 66.7%, 59.5%, 100.0%, and 85.2%, respectively. Bioassay-guided fractionation led to the isolation of inoscavin A from themethanolic extract of P. baumii, which showed the most potent activity and was identified by spectroscopic methods. Specifically,inoscavin A exhibited potent LOX inhibitory activity with an IC50 value of 6.8 μM.
|
|
|
KEYWORD
|
|
|
Inoscavin A, Korean native mushroom, Lipoxygenase inhibitor, Phellinus baumii
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
 
|
|