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KMID : 1160220140420020189
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Mycobiology
2014 Volume.42 No. 2 p.189 ~ p.192
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Neuraminidase Inhibitors from the Fermentation Broth of Phellinus linteus
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Hwang Byung-Soon
Lee Myeong-Seok
Lee Seung-Woong
Lee In-Kyoung
Seo Geon-Sik
Choi Hwa-Jung
Yun Bong-Sik
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Abstract
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During a search for neuraminidase inhibitors derived from medicinal fungi, we found that the fermentation broth ofPhellinus linteus exhibited potent neuraminidase inhibitory activity. Through bioassay-guided fractionation, two active compoundswere purified from the ethyl acetate-soluble portion of the fermentation broth of P. linteus. These structures were identified asinotilone (1) and 4-(3,4-dihydroxyphenyl)-3-buten-2-one (2) by spectroscopic methods. Compounds 1 and 2 inhibited H1N1neuraminidase activity with IC50 values of 29.1 and 125.6 μM, respectively, in a dose-dependent manner. They also exhibited anantiviral effect in a viral cytopathic effect reduction assay using MDCK cells. These results suggest that compounds 1 and 2 fromthe culture broth of P. linteus would be good candidates for the prevention and therapeutic strategies towards viral infections.
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KEYWORD
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4-(3, 4-Dihydroxyphenyl)-3-buten-2-one, Anti-influenza agent, Inotilone, Neuraminidase inhibitor, Phellinus linteus
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