|
KMID : 1160220140420040427
|
|
Mycobiology
2014 Volume.42 No. 4 p.427 ~ p.431
|
|
|
Mitochondrial Protein Nfu1 Influences Homeostasis of Essential Metals in the Human Fungal Pathogen Cryptococcus neoformans
|
|
Kim Jeong-Mi
Park Min-Ji
Do Eun-Soo
Jung Won-Hee
|
|
|
Abstract
|
|
|
|
Mitochondrial protein Nfu1 plays an important role in the assembly of mitochondrial Fe-S clusters and intracellulariron homeostasis in the model yeast Saccharomyces cerevisiae. In this study, we identified the Nfu1 ortholog in the human fungalpathogen Cryptococcus neoformans. Our data showed that C. neoformans Nfu1 localized in the mitochondria and influencedhomeostasis of essential metals such as iron, copper and manganese. Marked growth defects were observed in the mutant lackingNFU1, which suggests a critical role of Nfu1 in Fe-S cluster biosynthesis and intracellular metal homeostasis in C. neoformans.
|
|
|
KEYWORD
|
|
|
Cryptococcus neoformans, Fe-S cluster, Metals, Mitochondria, Nfu1
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
 
|