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KMID : 1160220150430030333
Mycobiology
2015 Volume.43 No. 3 p.333 ~ p.338
Antifungal Substances from Streptomyces sp. A3265 Antagonistic to Plant Pathogenic Fungi
Minh Nguyen Van

Woo E-Eum
Kim Ji-Yul
Kim Dae-Won
Hwang Byung-Soon
Lee Yoon-Ju
Lee In-Kyoung
Yun Bong-Sik
Abstract
In a previous study, we identified a Streptomyces sp., A3265, as exhibiting potent antifungal activity against various plant pathogenic fungi, including Botrytis cinerea, Colletotrichum gloeosporioides, and Rhizoctonia solani. This strain also exhibited a biocontrolling effect against ginseng root rot and damping-off disease, common diseases of ginseng and other crops. In this study, we isolated two antifungal substances responsible for this biocontrolling effect via Diaion HP-20 and Sephadex LH-20 column chromatography, medium pressure liquid chromatography, and high-performance liquid chromatography. These compounds were identified as guanidylfungin A and methyl guanidylfungin A by spectroscopic methods. These compounds exhibited potent antimicrobial activity against various plant pathogenic fungi as well as against bacteria.
KEYWORD
Biocontrol agent, Damping-off, Guanidylfungin, Streptomyces sp. A3265
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