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KMID : 1160220160440020117
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Mycobiology
2016 Volume.44 No. 2 p.117 ~ p.120
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Neuraminidase Inhibitors from the Fruiting Body of Phellinus igniarius
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Kim Ji-Yul
Kim Dae-Won
Hwang Byung-Soon
Woo E-Eum
Lee Yoon-Ju
Jeong Kyeong-Woon
Lee In-Kyoung
Yun Bong-Sik
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Abstract
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During our ongoing investigation of neuraminidase inhibitors from medicinal fungi, we found that the fruiting bodies of Phellinus igniarius exhibited significant inhibitory activity against neuraminidase from recombinant H3N2 influenza viruses. Two active compounds were isolated from the methanolic extract of P. igniarius through solvent partitioning and Sephadex LH-20 column chromatography. The active compounds were identified as phelligridins E and G on proton nuclear magnetic resonance (1H NMR) and electrospray ionization mass measurements. These compounds inhibited neuraminidases from recombinant rvH1N1, H3N2, and H5N1 influenza viruses, with IC50 values in the range of 0.7~8.1 μM.
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KEYWORD
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Neuraminidase inhibitor, Phelligridin E, Phelligridin G, Phellinus igniarius
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