|
KMID : 1160220180460030236
|
|
Mycobiology
2018 Volume.46 No. 3 p.236 ~ p.241
|
|
|
LAMMER Kinase Lkh1 Is an Upstream Regulator of Prk1-Mediated Non-Sexual Flocculation in Fission Yeast
|
|
Park Yoon-Dong
Kwon Soo-Jeong
Bae Kyung-Sook
Park Hee-Moon
|
|
|
Abstract
|
|
|
|
The cation-dependent galactose-specific flocculation activity of the Schizosaccharomyces pombe null mutant of lkh1+, the gene encoding LAMMER kinase homolog, has previously been reported by our group. Here, we show that disruption of prk1+, another flocculation associated regulatory kinase encoding gene, also resulted in cation-dependent galactose-specific flocculation. Deletion of prk1 increased the flocculation phenotype of the lkh1+ null mutant and its overexpression reversed the flocculation of cells caused by lkh1 deletion. Transcript levels of prk1+ were also decreased by lkh1+ deletion. Cumulatively, these results indicate that Lkh1 is one of the negative regulators acting upstream of Prk1, regulating non-sexual flocculation in fission yeast.
|
|
|
KEYWORD
|
|
|
Non-sexual flocculation, LAMMER kinase, Lkh1, Prk1, negative regulator, Schizosaccharomyces pombe
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
 
|