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KMID : 1160220200480020148
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Mycobiology
2020 Volume.48 No. 2 p.148 ~ p.152
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Antifungal Susceptibility Tests and the cyp51 Mutant Strains among Clinical Aspergillus fumigatus Isolates from Korean Multicenters
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Won Eun-Jeong
Joo Min-Young
Lee Da-In
Kim Mi-Na
Park Yeon-Joon
Kim Soo-Hyun
Shin Myung-Geun
Shin Jong-Hee
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Abstract
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We investigated the antifungal susceptibilities and the cyp51 mutant strains among Aspergillus fumigatus clinical isolates obtained from 10 university hospitals in Korea. Of the 84 isolates examined, two itraconazole-resistant isolates were found with no amino acid substitution in the cyp51A/cyp51B genes. However, 19 (23.2%) azole-susceptible isolates harbored amino acid substitutions: Nine isolates harbored one to five mutations in cyp51A with high polymorphism, and 11 isolates exhibited the same Q42L mutation in cyp51B. Overall, a low azole resistance rate and high frequency of cyp51A/cyp51B amino acid substitutions were observed in the azole-susceptible A. fumigatus isolates in Korea.
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KEYWORD
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Aspergillus fumigatus, antifungal susceptibility, cyp51A/cyp51B, multicentre
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