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KMID : 1160220220500010086
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Mycobiology
2022 Volume.50 No. 1 p.86 ~ p.95
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Cordycepin from Medicinal Fungi Cordyceps militaris Mitigates Inflammaging-Associated Testicular Damage via Regulating NF-κB/MAPKs Signaling in Naturally Aged Rats
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Kopalli Spandana Rajendra
Cha Kyu-Min
Cho Jae-Youl
Kim Si-Kwan
Koppula Sushruta
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Abstract
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Inflammaging in male reproductive organs covers a wide variety of problems, including sexual dysfunction and infertility. In this study, the beneficial effects of cordycepin (COR), isolated from potential medicinal fungi Cordyceps militaris, in aging-associated testicular inflammation and serum biochemical changes in naturally aged rats were investigated. Male Sprague Dawley rats were divided into young control (YC), aged control (AC), and COR (5, 10, and 20?mg/kg) treated aged rat groups. Aging-associated serum biochemical changes and inflammatory parameters were analyzed by biochemical assay kits, Western blotting, and real-time RT-PCR. Results showed a significant (p?
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KEYWORD
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Cordyceps militaris, inflammaging, MAPKs, interleukin, cytokines, testicular damage
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